Luxembourg’s Prince Frederik, the youngest son of Prince Robert and Princess Julie of Nassau, has passed away at the age of 22 after a long and courageous battle with POLG mitochondrial disease. His family announced his death in a heartfelt statement, remembering him as a fighter who remained positive despite the devastating effects of his illness.
Prince Frederik was diagnosed at 14 with POLG disease, a rare genetic disorder that affects the body’s ability to produce energy, leading to multiple organ failure over time. Though his health steadily declined, Frederik remained determined to raise awareness and advocate for research, even founding the POLG Foundation to support those affected by the disease.
In his final days, the young royal, who had lost his ability to speak, still found ways to communicate with his family. His father, Prince Robert, recalled Frederik’s strength, love for life, and even his humor in his last moments. "He is my superhero," Prince Robert said, describing his son’s unbreakable spirit.
POLG mitochondrial disease remains an untreatable condition, affecting millions worldwide. The prince’s passing has once again highlighted the urgent need for medical research and funding to find a cure.
Frederik is survived by his parents, his older brother Alexander, and his sister Charlotte. The Luxembourg royal family has asked that, in lieu of flowers, donations be made to the POLG Foundation, continuing Frederik’s mission to bring hope to those suffering from the disease.
His funeral is expected to take place in the coming days, with tributes pouring in from across Europe and beyond.